Differential diagnosis of neonatal and foetal alloimmune thrombocytopenias

(after Blanchette et al.)

  • Impaired poiesis
amegakaryocytic thrombocytopenias
thrombocytopenia-absent radius syndrome
amegakaryocytic thrombocytopenia
without anomalies of the extremities
Wiskott-Aldrich syndrome
bone-marrow infiltration (congenital leukaemia, neuroblastoma etc.)
osteopetrosis
  • Increased peripheral cell turnover
immunological
passive neonatal auto-immune thrombocytopenia (ITP)
non-immunological
DIG
giant hemangioma (Kasabach-Merritt syndrome)
eclampsia/HELLP syndrome of the mother
necrotising enterocolitis
  • Complex causes
infection
congenital (TORCH complex)
acquired (e.g. bacterial sepsis)
m. haemolyticus neonatorum
  • Miscellaneous
exchange transfusion
EKMO
polycythaemia
chromosomal abnormalities (e.g. Down's syndrome)

Hamburg und Bad Bramstedt, Dr. med. J. Neppert, Dr. med. E. v. Witzleben-Schürholz

© 2008 - 2016

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